Scientfic publications

[1]          M. C. Wehr, R. Laage, U. Bolz, T. M. Fischer, S. Grünewald, S. Scheek, A. Bach, K.-A. Nave, and M. J. Rossner, ‘Monitoring regulated protein-protein interactions using split TEV’, Nat. Methods, vol. 3, no. 12, pp. 985–993, Dec. 2006.

[2]          M. C. Wehr, L. Reinecke, A. Botvinnik, and M. P. Rossner, ‘Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV’, BMC Biotechnol., vol. 8, no. 1, p. 55, 2008.

[3]          A. Genevet, M. C. Wehr, R. Brain, B. J. Thompson, and N. Tapon, ‘Kibra is a regulator of the Salvador/Warts/Hippo signaling network’, Dev. Cell, vol. 18, no. 2, pp. 300–308, Feb. 2010.

[4]          A. Botvinnik, S. P. Wichert, T. M. Fischer, and M. J. Rossner, ‘Integrated analysis of receptor activation and downstream signaling with EXTassays’, Nat. Methods, vol. 7, no. 1, pp. 74–80, Jan. 2010.

[5]          D. C. Gray, S. Mahrus, and J. A. Wells, ‘Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease’, Cell, vol. 142, no. 4, pp. 637–646, Aug. 2010.

[6]          M. S. Djannatian, S. Galinski, T. M. Fischer, and M. J. Rossner, ‘Studying G protein-coupled receptor activation using split-tobacco etch virus assays’, Anal. Biochem., vol. 412, no. 2, pp. 141–152, May 2011.

[7]          A. Botvinik and M. J. Rossner, ‘Linking cellular signalling to gene expression using EXT-encoded reporter libraries’, Methods Mol. Biol. Clifton NJ, vol. 786, pp. 151–166, 2012.

[8]          A. Botvinik and M. J. Rossner, ‘Integrated measurement of split TEV and cis-regulatory assays using EXT encoded reporter libraries’, Methods Mol. Biol. Clifton NJ, vol. 812, pp. 309–323, 2012.

[9]          X. Capdevila-Nortes, T. López-Hernández, F. Ciruela, and R. Estévez, ‘A modification of the split-tobacco etch virus method for monitoring interactions between membrane proteins in mammalian cells’, Anal. Biochem., Jan. 2012.

[10]        M. C. Wehr, M. V. Holder, I. Gailite, R. E. Saunders, T. M. Maile, E. Ciirdaeva, R. Instrell, M. Jiang, M. Howell, M. J. Rossner, and N. Tapon, ‘Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila’, Nat. Cell Biol., vol. 15, no. 1, pp. 61–71, Jan. 2013.

[11]         M. C. Wehr, S. Galinski, and M. J. Rossner, ‘Monitoring G Protein-Coupled Receptor Activation Using the Protein Complementation Technique Split TEV’, Methods Mol. Biol., vol. 1272, pp. 107–118, 2015.

[12]        M. C. Wehr and M. J. Rossner, 'Split protein biosensor assays in molecular pharmacological studies', Drug. Disc. Today, vol. 21, no. 3, pp. 415-429, Mar. 2016.

[13]        J. P. Wintgens, M. J. Rossner, and M. C. Wehr, 'Characterizing Dynamic Protein-Protein Interactions Using the Genetically Encoded Split Biosensor Assay Technique Split TEV', Methods Mol. Biol., vol 1596, pp. 219-238, 2017

[14]       M. C. Wehr, W. Hinrichs, M. M. Brzózka, T. Unterbarnscheidt, A. Herholt, S. Papiol, M.C. Soto-Bernardini, M. Kravchenko, M Zhang, K.-A. Nave, S. P. Wichert, P. Falkai, W. Zhang, M. H. Schwab, and M. J. Rossner, 'Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice', EMBO Mol. Med., vol. 10, pp. 1448-1462, Oct. 2017.

[15]     S. Galinski, S. P. Wichert, M. J. Rossner, and M. C. Wehr, ‘Multiplexed profiling of GPCR activities by combining split TEV assays and EXT-based barcoded readouts’, Sci. Rep., vol. 8, no. 1, p. 8137, May 2018.




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